I'm absolutely loving Windows Vista 64-bit. I'm never ever going with a 32-bit OS ever again. I love not having to sweat memory anymore.
Once we get people away from 32-bit OSes, we will see an explosion of next-generation apps. Right now, in 2008, we still have people worrying about apps that use 20 megs of RAM.
I look forward to a laptop with 16GB of RAM. It says something about how limiting our OS is when we have SSD units at 128GB but systems with only 2GB of RAM (RAM is much cheaper).